Table 1. Demographic and Clinical Characteristics.
| Characteristic | Participants with OCD | Participants without OCD | P-value |
|---|---|---|---|
| (N=30) | (N=29) | ||
| Age, years, mean (SD) | 32.0 (11.5) | 32.4 (12.1) | 0.91a |
| Range | 18–54 | 18–55 | |
| Sex | |||
| Male, N (%) | 18 (60) | 13 (45) | 0.30b |
| Female, N (%) | 12 (40) | 16 (55) | |
| Age of OCD onset, years, mean (SD) | 13.3 (6.6) | — | |
| Duration of OCD, years, mean (SD) | 19.0 (12.9) | — | |
| Yale–Brown Obsessive-Compulsive Scale, mean (SD) | 27.8 (2.6) | 0 | |
| Montgomery–Asberg Depression Rating Scale, mean (SD) | 17.1 (7.5) | 0.66 (1.0) | |
| Predominant OCD symptom dimension | |||
| Contamination, N (%) | 19 (64) | — | |
| Aggression, N (%) | 4 (13) | — | |
| Sexual/religious, N (%) | 3 (10) | — | |
| Symmetry/exactness, N (%) | 4 (13) | — | |
| DSM-IV axis I psychiatric comorbidity at the time of study | |||
| None, N (%) | 10 (33) | — | |
| Major depressive disorder, N (%) | 11 (37) | — | |
| Dysthymic disorder, N (%) | 3 (10) | — | |
| Panic disorder, N (%) | 3 (10) | — | |
| Social anxiety disorder, N (%) | 3 (10) | — | |
| Anorexia nervosa, N (%) | 1 (3) | — | |
| Bulimia nervosa, N (%) | 1 (3) | — | |
| Body dysmorphic disorder, N (%) | 2 (7) | — | |
| Trichotillomania, N (%) | 1 (3) | — | |
| Posttraumatic stress disorder, N (%) | 1 (3) | — | |
| Medications at the time of study | |||
| None, N (%) | 6 (20) | — | |
| SSRI, N (%)c | 18 (60) | — | |
| SNRI, N (%)d | 1 (3) | — | |
| Clomipramine, N (%) | 4 (13) | — | |
| Second-generation antipsychotic, N (%)e | 6 (20) | — | |
| Benzodiazepine, N (%)f | 14 (47) | — | |
| Other, N (%) | 4 (13) | — | |
| Bupropion | 2 (7) | — | |
| Lithium | 1 (3) | — | |
| Trazodoneg | 1 (3) | — | |
| Zolpidemg | 1 (3) | — | |
| Naltrexoneg | 1 (3) | — | |
| Number of weeks on stable dose of medication | |||
| SSRI/SNRI/Clomipramine, mean (SD, range) | 51 (109, 4–120) | — | |
| Second-generation antipsychotic, mean (SD, range) | 35 (37, 12–108) | — | |
| Benzodiazepine, mean (SD, range) | 91 (133, 8–520) | — | |
| Other, mean (SD, range) | 175 (232, 36–520) | — | |
Abbreviations: OCD, obsessive–compulsive disorder; SNRI, serotonin–norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.
a
By t-test (two tailed).
b
By Fisher's exact test (two tailed).
c
Fluoxetine (N=8), sertraline (N=7), escitalopram (N=2), and citalopram (N=1).
d
Venlafaxine (N=1).
e
Risperidone (N=3) and aripiprazole (N=3).
f
Clonazepam (N=7), lorazepam (N=5), alprazolam (N=1), and clorazepate (N=1).
g
Used by the same participant.