Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 4;40(8):1877–1887. doi: 10.1038/npp.2015.37

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 American College of Neuropsychopharmacology

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

PMC Copyright notice

Anemoside A3 (AA3) enhances signaling proteins activation in the mouse hippocampus. Treatment with AA3 (30 μM) increased ERK1 (a) and ERK2 (b) phosphorylation in acute rat hippocampal slices. (c) AA3 increased cAMP levels in acute hippocampal slices. n=3; *p<0.05 vs 0 μM. (d–h) AA3 (100 mg/kg) enhanced CREB, ERK1/2, CaMKIIα, and AKT phosphorylation in the mouse hippocampus. Mice were orally administered AA3 daily for 2 days. Ratios of pCREB/actin (d), pERK1/ERK1 (e), pERK2/ERK2 (f), pCaMKIIα/CaMKIIα (g), and pAKT/AKT (h). (i and j) AA3 increased brain-derived neurotrophic factor (BDNF) but not actin protein levels in the mouse hippocampus. n=4 mouse brains, *p<0.05, **p<0.005 vs control (Cont).