Table 1. AA3 Administration Increases Amounts of 5-HT, 5-HIAA, and NE in the Mouse Hippocampus (a) and Prefrontal Cortex (b).
|
Monoamine neurotransmitter level (ng/g wet tissue) |
||||
|---|---|---|---|---|
| 5-HT | HIAA | NE | HIAA/5-HT | |
| a) Hippocampus | ||||
| Control | 496.1±59.54 | 746.3±85.07 | 419.9±42.87 | 1.51±0.06 |
| AA3 (30 mg/kg) | 864.5±37.88* | 994.5±34.66* | 672.5±35.53** | 1.15±0.04 |
| AA3 (100 mg/kg) | 827.9±108.6** | 1108±58.66** | 710.3±55.64** | 1.43±0.19 |
| b) Prefrontal cortex | ||||
| Control | 1007±205.6 | 415.9±45.27 | 524.5±30.6 | 0.44±0.03 |
| AA3 (30 mg/kg) | 3029±1383 | 539.8±37.16* | 743.6±31.37* | 0.26±0.05* |
| AA3 (100 mg/kg) | 2060±158.1 | 623.3±32.2** | 874.1±78.56** | 0.31±0.02 |
Abbreviation: AA3, Anemoside A3.
Hippocampus (5-HT: F(2, 12)=7.365, p=0.008; 5-HIAA F(2, 12)=8.632, p=0.005; NE: F(2, 12)=12.07, p=0.001; HIAA/5-HT: F(2, 12)=2.405, p=0.132). Prefrontal cortex (5-HT: F(2, 12)=1.55, p=0.252; 5-HIAA F(2, 12)=7.315, p=0.008; NE: F(2, 12)=11.57, p=0.002; HIAA/5-HT: F(2, 12)=6.539, p=0.012). n=5 mice per group, *p<0.05, **p<0.01 vs Control.