Figure 3.

Amphetamine (AMPH) reverses the decrease in membrane-associated expression of the dopamine transporter that follows cocaine self-administration (Coc SA) as measured by western blot analysis. (a) Representative blots of all four treatment groups. (b) Total DAT expression shows significant decreases following Coc SA that is reversed by an AMPH infusion. (c) No significant shift in cytosolic DAT levels across all four groups. (d) Membrane-associated DAT localization shows significant decreases following Coc SA that is reversed by an AMPH infusion, in addition to decreases in naive animals following AMPH infusion. *P<0.05 vs Naive+Saline; ^#p<0.05 vs Coc SA+Saline; ^Δp<0.05 vs Naive+AMPH.