Figure 1.

1-CSRT task separates impulsive action phenotypes. (a) Ordinal ranking of a representative cohort (cohort 3) based on premature responses averaged over two ITI8 challenge sessions. Low-impulsive (LI, n=8, open circles) and high-impulsive rats (HI, n=8, closed circles) were defined by lower and upper quartiles, respectively, from mid-impulsive rats (MI, n=13, gray circles). (b) HI rats (black bars) exhibit elevated premature responses vs LI rats (white bars) in all cohorts during performance in ITI8 challenge sessions and (c) during stable performance in ITI5 maintenance sessions, as averaged over 2 to 3 days before subsequent experimentation (*p<0.05 vs LI, ^#p=0.06).