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. 2015 Mar 18;40(8):1957–1968. doi: 10.1038/npp.2015.46

Figure 3.

Figure 3

HI rats are more sensitive to the behavioral effects of M100907, but not DOI, in the 1-CSRT task. Following 1-CSRT task training and phenotypic identification, the effects of DOI (0.01, 0.03, and 0.1 mg/kg; cohort 2) and M100907 (0.001, 0.01, and 0.1 mg/kg; cohort 3) were each evaluated in separate cohorts of rats under ITI5 conditions. In both cohorts, baseline levels of premature responses in HI rats administered vehicle (VEH; closed circles, upper dotted line) were significantly higher than the vehicle baseline in LI rats (open circles, lower dashed line; *p<0.05 vs LI-VEH). (a) In both HI (n=9) and LI rats (n=7), DOI significantly increased premature responses at 0.03 mg/kg (#p<0.05 vs HI-VEH, *p<0.05 vs LI-VEH). (b) In HI rats (n=8), M100907 significantly suppressed premature responses at 0.01 and 0.1 mg/kg (#p<0.05 vs HI-VEH), below the vehicle baseline of LI rats (n=8). Only the highest dose of M100907 (0.1 mg/kg) significantly suppressed premature responses in LI rats (*p<0.05 vs LI-VEH).