Figure 3.

Effect of pretest administration of A-988315 on stress-induced impairment of retrieval of object-location memory. (a) Schematic illustration of training procedure, and drug and stress exposure. (b) Total time (in s) spent exploring both identical objects during the 10-min training session, before drug administration or stress exposure. (c) Discrimination index (in %) during the 3-min retention test trial. (d) Total time (in s) spent exploring both objects during the retention test trial. (e) Total number of quadrant crossings during the retention test trial as a measure of exploration of the experimental context. All data are expressed as mean+SEM. **P<0.01 compared with the corresponding water group. ^♦♦P<0.01 compared with the corresponding non-stress group. Number of rats per group—non-stress groups: water, n=10; 20 mg/kg, n=10; and 60 mg/kg, n=11; and stress groups: water, n=11; 20 mg/kg, n=10; and 60 mg/kg, n=11.