Table 1. Affinity of A-988315 in Binding to Human and Rat Vasopressin V1b, V1a, V2 Receptors, and Oxytocin Receptors.
|
Ki values (nM, geomeans, and 95% CI, n=4) |
||||
|---|---|---|---|---|
| Species | V1b | V1a | V2 | OT |
| Human | 0.53 (0.39–0.71) | 50 (32–62) | >10 000 | 8.3 (6.8–10) |
| Rat | 3.8 (2.7–5.4) | 121 (102–141) | Not determined | 90 (77–100) |
Abbreviations: CI, confidence interval; OT, oxytocin.
Ki values (nM, geomeans and 95% CI, n=4) obtained in radioligand displacement assays using membranes expressing recombinant rat or human receptors.