Fig 2.

Kaplan Meier survival curves for MSSA (a) and MRSA (b) infected mice. All mice were infected with 10⁹cfu of S. aureus intraperitoneally. For the MSSA assay, each group of mice was pretreated with 25 mg/kg of a compound 30 minutes before inoculation and was also given an additional 25 mg/kg dose 1 hour after inoculation. Control mice were injected twice with the vehicle at the same time-points as treated mice. The survival curves are the combined result of two repeat experiments. Both experiments showed similar findings. For the MRSA murine infection model, each group of mice was treated with two doses of 25 mg/kg of a compound, 15 minutes and 3 hours after inoculation. Control mice were injected twice with the vehicle at the same time-points as treated mice. Eight mice were used per group. Survival was plotted using Kaplan Meier curves and p-values were calculated using the log-rank test.