Table 5. Results of Two-Way Repeated Measures ANOVA comparing the Main Effects of Duration (time) and mode of hypoxia across the three hypoxia groups.

	Mode of hypoxia		Time		Interaction
	F	P value	F	P value	F	P Value
SpO2	6.55	0.004ac	2.4	0.10	1.2	0.34
Heart Rate	2.32	0.12	75.47	<0.001abc	2.18	0.08
Mitral E velocity	0.17	0.84	11.97	<0.001ac	1.2	0.32
Mitral A velocity	1.20	0.33	5.9	0.005ac	0.35	0.85
Mitral E/A ratio	1.93	0.16	10.79	<0.0001	0.43	0.79
Septal S’ velocity	2.38	0.11	0.99	0.38	0.72	0.58
Septal E’ velocity	0.20	0.82	3.37	0.04b	0.77	0.55
Septal A’ velocity	0.29	0.75	12.32	<0.001ab	0.36	0.83
Septal ICV	1.0	0.40	2.70	0.08	1.0	0.42
Lateral S’ velocity	1.40	0.27	10.28	<0.001ab	3.99	0.006
Lateral E’ velocity	2.20	0.13	7.56	0.001 ab	1.12	0.36
Lateral A’ velocity	0.40	0.68	6.97	0.002ab	0.58	0.68
Lateral ICV	0.12	0.89	6.99	0.002a	2.14	0.09
LV Tei Index	2.32	0.12	6.48	0.003a	1.54	0.10
LV stroke volume	0.39	0.68	10.37	0.004 ab	0.93	0.45
Cardiac output	0.23	0.80	13.8	<0.001ab	2.52	0.06
RVSP	0.70	0.51	1.47	0.24	0.88	0.48
Pulmonary vascular resistance	2.10	0.14	5.85	0.005 ab	0.27	0.76
Tricuspid E velocity	0.55	0.58	5.15	0.009a	0.88	0.48
Tricuspid A velocity	3.90	0.03a	1.9	0.16	0.58	0.68
TAPSE	1.21	0.31	1.1	0.31	2.4	0.06
Tricuspid S’ velocity	2.60	0.09	1.3	0.30	3.12	0.02
Tricuspid E’ velocity	0.66	0.53	0.01	0.99	0.10	0.98
Tricuspid A’ velocity	8.20	0.002a	22.3	<0.001 ab	1.59	0.19
Tricuspid ICV	3.40	0.048 a	6.7	0.002a	0.78	0.54
Right ventricular Tei Index	5.0	0.01c	16.10	<0.001ab	4.10	0.006

TAPSE, trans annular plane systolic excursion; RVSP, right ventricular systolic pressure; ICV isovolumic contractile velocity; Results of post hoc tests–time: a baseline versus 15 minutes post exercise, b baseline versus 2h post exercise, c 15 minutes versus 2 hours post exercise, altitude: a GHA vs NH, b GHA vs HH, c NH vs HH