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Physicochemical characterization of nanoparticles.
| NP construct | Particle size (nm ± SD) | Zeta potential (mV ± SD) | PDI | Encapsulation efficiency (%) | PLC (μg/100 mg NP) |
|---|---|---|---|---|---|
| CpG-NP-Blank | 211.8 ± 79 | −4.22 ± 0.2 | 0.137 | – | – |
| NP-Tag | 221.3 ± 75 | −3.62 ± 0.4 | 0.115 | 32.2 ± 2.1 | 183 |
| CpG-NP-Tag | 227.4 ± 40 | −6.73 ± 0.3 | 0.031 | 32.2 ± 2.1 | 183 |
NP: Nanoparticle; PDI: Polydispersity Index; PLC: Protein (tumor antigen)-loading content; SD: Standard deviation.
