Table I.
Sample characteristics.
|
BRCA1 |
BRCA2 |
|||||
|---|---|---|---|---|---|---|
| Carriers | Non-Carriers | P-value | Carriers | Non-Carriers | P-value | |
| n = 172 | n = 216 | n = 147 | n = 158 | |||
| Year of birth* | 1968 (7.2) | 1966 (6.9) | 0.003 | 1969 (7.0) | 1967 (7.0) | 0.01 |
| Age at blood draw (years)* | 34.2 (5.7) | 35.8 (5.8) | 0.006 | 34.4 (5.6) | 35.8 (5.6) | 0.03 |
| Years sample was stored* | 11.4 (3.9) | 11.9 (3.3) | 0.15 | 10.8 (3.7) | 11.4 (3.6) | 0.17 |
| Cigarette use**, n (%) | ||||||
| Never | 84 (49) | 97 (45) | 75 (51) | 76 (48) | ||
| Past | 39 (23) | 64 (30) | 45 (31) | 46 (29) | ||
| Current | 49 (28) | 55 (25) | 0.31 | 27 (18) | 36 (23) | 0.65 |
| Body mass index* (kg/m2) | 24.8 (5.2) | 26.2 (6.4) | 0.02 | 25.4 (6.0) | 25.4 (5.3) | 0.99 |
| OCP use at blood draw, n (%) | ||||||
| No | 150 (87) | 183 (85) | 118 (80) | 139 (88) | ||
| Yes | 22 (13) | 33 (15) | 0.56 | 29 (20) | 19 (12) | 0.08 |
| Infertility treatment, n (%) | ||||||
| Ever | 10 (6) | 10 (5) | 8 (5) | 11 (7) | ||
| Never | 161 (94) | 205 (95) | 0.65 | 135 (92) | 142 (90) | 0.64 |
| Don't know | 1 (1) | 1 (0.5) | 4 (3) | 5 (3) | ||
| Parity, n (%) | ||||||
| Nulliparous | 46 (27) | 65 (30) | 53 (36) | 48 (30) | ||
| Parous | 126 (73) | 151 (70) | 0.50 | 94 (64) | 110 (69) | 0.33 |
| Age at first birth* (years) | 24.9 (4.7) | 25.0 (5.1) | 0.76 | 25.7 (4.4) | 25.6 (4.7) | 0.87 |
All values <0.05 are statistically significant.
n, number; OCP, oral contraceptive pill.
*Mean (standard deviation).
**Regular cigarette smoking—at least one per day for 3 months or longer.