Table 4.
Change in lean mass, muscle strength and bone mineral density in women randomized to 2000 IU vitamin D3/day who did vs. did not become replete (25(OH)D ≥32ng/mL) by 12 months
| 25(OH)D <32ng/mL | 25(OH)D ≥32ng/mL | |||||
|---|---|---|---|---|---|---|
| Baseline Mean (SD) | Change | Baseline Mean (SD) | Change | p1 | p2 | |
|
|
||||||
| Serum 25(OH)D | 19.2 (5.5) | 7.2 | 23.5 (5.7) | 18.02 | <0.001 | <0.001 |
| Lean mass (kg) | 41.8 (4.6) | 2.8 | 41.7 (5.2) | 4.3 | 0.82 | 0.83 |
| Lean mass (%) | 47.9 (5.3) | −1.2 | 49.3 (5.3) | −1.1 | 0.11 | 0.33 |
| Appendicular lean mass (kg) | 17.1 (2.2) | −0.3 | 16.9 (2.4) | −0.2 | 0.93 | 0.98 |
| R femoral neck BMD (g/cm2) | 0.94 (0.09) | 0.0 | 0.96 (0.10) | −0.01 | 0.44 | 0.75 |
| R femoral neck BMD T-score | −0.5 (0.8) | 0.0 | −0.4 (0.8) | −0.1 | 0.74 | 0.93 |
| Spine BMD (g/cm2) | 1.14 (0.13) | 0.0 | 1.12 (0.13) | 0.0 | 0.6 | 0.39 |
| Spine BMD T-score | −0.3 (1.0) | −0.1 | −0.5 (1.1) | 0.0 | 0.89 | 0.49 |
| Muscle Strength | ||||||
| 1-RM chest press (lbs) | 50.9 (13.3) | 1.4 | 56.9 (14.8) | −6.0 | 0.14 | 0.23 |
| 1 RM leg press (lbs) | 171.5 (49.1) | 2.3 | 181.7 (37.7) | −10.2 | 0.09 | 0.59 |
BMD=Bone Mineral Density; RM= Repetition Maximum
p1
Unadjusted
p2
Adjusted for age, ethnicity, baseline BMI, baseline serum 25(OH)D, season of randomization, vitamin D intake (diet + supplements), total calcium intake, protein intake (g/day), average sun exposure