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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Pigment Cell Melanoma Res. 2016 Mar 15;29(3):297–308. doi: 10.1111/pcmr.12455

Figure 5. mPGES1 inhibition suppressed human melanoma cell survival.

Figure 5

(A) A375 cells were injected subcutaneously into the flanks of nude mice. Mice were randomized into the following treatment groups (n=7): Vehicle, CAY10526 (25 mg/kg), or CAY10526 (50 mg/kg). Mice were treated from day 7 after injection to day 15 and tumor size was measured with an external caliper. (B) Tumor weight at the end of the experiment. (C) Tumor tissues from mice treated with vehicle and CAY10526 (50 mg/kg) were immunostained for phosphorylated Y-box binding protein 1 (p-YB-1) and cleaved caspase 3 (CC3).