Table 4.
Univariate Analysis | Multivariable Analysis* | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
HR | SE | z | p-value | 95% CI | HR | SE | Z | p-value | 95% CI | |
Non-Diabetic Donor | ||||||||||
Diabetic Recipient | 1.990 | 0.045 | 30.72 | < 0.001 | 1.905-2.080 | 1.932 | 0.063 | 20.20 | < 0.001 | 1.812-2.060 |
Non-Diabetic Recipient | REF | REF | ||||||||
Diabetic Donor | ||||||||||
Diabetic Recipient | 1.847 | 0.156 | 7.24 | < 0.001 | 1.564-2.180 | 1.532 | 0.179 | 3.64 | < 0.001 | 1.218-1.927 |
Non-Diabetic Recipient | REF | REF | ||||||||
Recipient Characteristics | ||||||||||
Age > 40 | 1.837 | 0.085 | 13.21 | < 0.001 | 1.679-2.011 | 1.928 | 0.125 | 10.12 | < 0.001 | 1.698-2.189 |
Male | 1.118 | 0.036 | 3.47 | 0.001 | 1.050-1.191 | 1.025 | 0.046 | 0.54 | 0.591 | 0.937-1.120 |
African American Race | 0.996 | 0.038 | −0.12 | 0.907 | 0.924-1.072 | 0.954 | 0.052 | −0.87 | 0.386 | 0.858-1.061 |
Pre-Transplant Dialysis** | 1.058 | 0.006 | 9.30 | < 0.001 | 1.046-1.071 | 1.052 | 0.009 | 5.96 | < 0.001 | 1.035-1.070 |
Time on Waitlist (days) | 1.000 | 0.000 | 2.85 | 0.004 | 1.000-1.000 | |||||
Prior Renal Transplant | 1.047 | 0.059 | 0.83 | 0.409 | 0.938-1.169 | 1.200 | 0.102 | 2.16 | 0.031 | 1.017-1.417 |
HCV+ | 0.647 | 0.228 | −1.24 | 0.216 | 0.324-1.291 | 1.090 | 0.116 | 0.81 | 0.417 | 0.885-1.343 |
Max PRA ≥30 | 1.162 | 0.051 | 3.41 | 0.001 | 1.066-1.267 | |||||
≥ 1 HLA Mismatch | 1.011 | 0.071 | 0.16 | 0.873 | 0.881-1.160 | |||||
Obese (BMI >=30) | 1.036 | 0.036 | 1.03 | 0.304 | 0.968-1.109 | |||||
Cold Ischemia Time | 1.007 | 0.003 | 2.83 | 0.005 | 1.002-1.012 | |||||
Delayed Graft Function | 1.942 | 0.043 | 30.32 | < 0.001 | 1.486-1.734 | |||||
Acute Rejection at 1 Year | 1.396 | 0.077 | 6.03 | < 0.001 | 1.252-1.555 | |||||
No Induction Immunosuppression |
0.995 | 0.039 | −0.12 | 0.906 | 0.921-1.076 |
Tacrolimus and the interaction term between tacrolimus and time were also included in the multivariable model
Included as an interaction term along with duration of dialysis or diabetes, as appropriate