Table 1.

This table presents the most important attributes confirmed, based on different weighting algorithms, to be involved in the substrate specificity of ATPase pumps (Values closer to 1 shows higher effectiveness of features). Weighting algorithms were PCA, relief, uncertainty, gini index, chi squared, deviation, rule, correlation, gain ratio, and information gain

Weighting method	Attribute	Weight
Weighting by PCA	Non-reduced coefficient pertaining to Cys extinction within 280 nm	1.00
Weighting by SVM	Val frequency	0.9
	Phe-Phe count	0.7
	Val count	0.7
	Non-reduced absorption at 280 nm	0.7
	Val-Ala count	0.9
	Gly-Ser count	0.8
	Gly-Leu count	1.0
	Met-Ala count	0.7
	Ile-Asn count	0.8
	Lys-Ala count	0.9
	Ala-Val count	0.8
	Lys-Ala frequency	0.7
	Val-Gly count	0.7
	Ile-Gly count	0.8
	Ser-Glu count	0.8
	Cys-Pro count	0.7
	Gly-Thr count	0.7
	Met-Gly count	0.7
	Glu-Gly count	0.7
	Gly-Ala count	0.8
Weighting by relief	Non-reduced coefficient pertaining to Cys extinction within 280 nm	0.8
	Val frequency	0.7
	Val count	0.7
	Hydrophilic residues frequency	0.7
	Ser count	0.7
	Phe count	0.7
	Tyr count	0.9
	Hydrophilic residues count	1.0
	Length	0.7
	Pro-Gly count	0.7
	Glu-Tyr count	0.7
	Phe-Arg count	0.7
	Tyr-Leu count	0.7
	Met-Tyr count	0.8
	Cys-Tyr count	1.0
	Leu-Tyr count	0.7
	Trp-Cys count	0.8
Weighting by uncertainty	Non-reduced coefficient pertaining to Cys extinction within 280 nm	0.9
	Hydrogen frequency	0.7
	Val frequency	0.7
	Phe-Phe count	0.7
	count of Val	0.9
	Carbon frequency	1.0
	Hydrophilic residues frequency	0.8
	Non-reduced Absorption at 280 nm	0.7
	Val-Ala count	0.7
	Ser count	0.7
	Phe count	0.8
	Tyr count	0.7
	Hydrophilic residues count	0.9
	Length	1.0
	Trp frequency	0.7
	Ser frequency	0.8
	Gly frequency	0.7
	Hydrophobic residues frequency	0.7
	Cys count	0.7
	Phe-Asn count	0.7
	Glu-Tyr count	0.7
	Phe-Arg count	0.7
	Tyr-Glu count	0.7
	Arg-Thr count	0.7
	Sulphur count	0.7
	Leu count	0.7
	Hydrophilic other count	0.7
	Hydrophobic residues count	0.8
	Gln-Ser count	0.7
	Val-Gln count	0.7
	Met-Tyr count	0.7
	Cys-Tyr count	0.7
	Leu-Leu count	0.7
	Cys-Glu count	0.7
	Ile-Phe count	0.7
Weighting by gini index	Non-reduced coefficient pertaining to Cys extinction within 280 nm	1.0
	Hydrogen frequency	0.9
	Val frequency	1.0
	Val count	0.9
	Carbon frequency	1.0
	Hydrophilic residues frequency	0.8
	Non-reduced Absorption at 280 nm	0.9
	Phe-Leu count	0.9
	Val-Ala count	0.8
	Ser count	0.8
	Arg count	0.9
	Phe count	0.9
	Tyr count	1.0
	Hydrophilic residues count	0.9
	Length	0.9
	Gly frequency	0.8
	Cys count	0.8
	Hydrophilic other count	0.8
	Hydrophobic residues count	0.9
	Phe-Met count	0.8
	Trp-Tyr count	0.9
	Cys-Tyr count	0.9
	Leu-Tyr count	0.9
	Ser-Ser count	0.8
	Ala frequency	0.7
	Phe-Phe count	0.7
	Ala-Ile count	0.7
	Ile frequency	0.7
	Ser frequency	0.7
	Phe-Asn count	0.7
	Pro-Gly count	0.7
	Gly-Ser count	0.7
	Gly-Leu count	0.7
	Tyr-Leu count	0.7
	Thr count	0.7
	Leu count	0.7
	Arg frequency	0.7
	Asp-Ala count	0.7
	Val-Gln count	0.7
	Ile-Ala count	0.7
	Tyr-Arg count	0.7
	Leu-Phe count	0.7
	Aliphatic index	0.7
	Cys-Asn count	0.7
	Ile-Tyr count	0.7
	Phe-Tyr count	0.7
	Asn-Leu count	0.7
Weight scrutiny through Chi squared	Non-reduced coefficient pertaining to Cys extinction within 280 nm	1.0
	Hydrogen frequency	0.7
	Val frequency	0.7
	Val count	0.8
	Carbon frequency	1.0
	Hydrophilic residues frequency	0.8
	Non-reduced absorption at 280 nm	0.7
	Asp count	0.7
	Ser count	0.7
	Phe count	0.8
	Hydrophilic residues count	0.9
	Length	0.9
	Trp frequency	0.7
	Ser frequency	0.9
	Glu count	0.7
	Hydrophilic other count	0.7
	Hydrophobic residues count	0.7
	Leu-Leu count	0.7
	Ile-Phe count	0.7
Weight Scrutiny through deviation	Non-reduced coefficient pertaining to Cys extinction within 280 nm	1.00
Weight scrutiny through rule	Non-reduced coefficient pertaining to Cys extinction within 280 nm	1.0
	Val count	0.7
	Carbon frequency	0.8
	Non-reduced absorption at 280 nm	0.9
	Asp count	0.7
	Ser count	0.7
	Arg count	0.7
	Phe count	0.8
	Hydrophilic residues count	0.9
	Length	0.9
	Ser frequency	0.8
	Hydrophobic residues frequency	0.7
	Sulphur count	0.7
	Leu count	0.7
	Negatively Charged (D & E) count	0.7
	Hydrophilic other count	0.8
	Hydrophobic residues count	1.0
	Index of Aliphatic	1.0
	Point of Isoelectric	1.0
Weight Scrutiny through Gain Ratio	Non-reduced coefficient pertaining to Cys extinction within 280 nm	1.0
	Hydrogen frequency	0.9
	Ala frequency	0.7
	Val frequency	1.0
	Val count	0.9
	Carbon frequency	1.0
	Hydrophilic residues frequency	0.9
	Non-reduced absorption at 280 nm	0.9
	Ala-Ile count	0.7
	Phe-Leu count	0.9
	Val-Ala count	0.8
	Asp count	0.8
	Ser count	0.9
	Arg count	0.9
	Phe count	0.9
	Tyr count	1.0
	Hydrophilic residues count	0.9
	Length	0.9
	Ile frequency	0.8
	Ser frequency	0.7
	Gly frequency	0.8
	Hydrophobic residues frequency	0.7
	Cys count	0.9
	Pro-Gly count	0.7
	Glu-Thr count	0.7
	Tyr-Leu count	0.7
	Tyr-Glu count	0.7
	Arg-Thr count	0.7
	Thr count	0.7
	Glu count	0.8
	Leu count	0.7
	Hydrophilic other count	0.7
	Hydrophobic residues count	0.9
	Ser-Trp count	0.8
	Phe-Met count	0.9
	Met-Ala count	0.8
	Val-Gln count	0.8
	Trp-Met count	0.7
	Ile-Ala count	0.8
	Trp-Tyr count	0.9
	Cys-Tyr count	0.9
	Leu-Phe count	0.7
	Leu-Tyr count	0.9
	Aliphatic index	0.7
	Trp count	0.7
	Ser-Ser count	0.9
	Lys-Ala count	0.8
	Ser-Val frequency	0.7
	Lys-Ala frequency	0.7
	Met count	0.7
	Glu-Met count	0.7
Weighting by info gain	Non-reduced coefficient pertaining to Cys extinction within 280 nm	0.8
	Hydrogen frequency	0.7
	Ala frequency	0.7
	Val frequency	1.0
	Val count	0.7
	Carbon frequency	0.8
	Hydrophilic residues frequency	0.7
	Non-reduced absorption at 280 nm	0.9
	Phe-Leu count	0.7
	Val-Ala count	0.8
	Asp count	0.8
	Ser count	0.7
	Arg count	0.8
	Phe count	0.8
	Tyr count	0.8
	Hydrophilic residues count	0.8
	Length	0.8
	Gly frequency	0.7
	Hydrophobic residues frequency	0.7
	Cys count	0.7
	Pro-Gly count	0.7
	Glu-Thr count	0.7
	Thr count	0.7
	Leu count	0.7
	Hydrophobic residues count	0.7
	Ser-Trp count	0.7
	Phe-Met count	0.7
	Met-Ala count	0.7
	Trp-Tyr count	0.7
	Cys-Tyr count	0.7
	Leu-Phe count	0.7
	Leu-Tyr count	0.7
	Ser-Ser count	0.7