Fig. 7.

Specificity of N42FTA and opportunities for further design.

(a) Superposition of N42FTA PaFabA complex and PaFabZ [23]. The colour scheme of the atoms from the PaFabA complex is as Fig. 6a, atoms from the A subunit of PaFabZ are coloured dark green and the B subunit is in blue. The side chains of L11 and L86 from PaFabZ clash with the chlorobenzene group due to changes in the hydrophobic tunnel that are key to the differences in FabA and FabZ activity. Space-fill representations of the tunnels are shown in Fig. S5.

(b) Superposition of N42FTA complex and the four fragment complexes previously reported [24].