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. 2015 Aug 9;20:727–736. doi: 10.1007/s00784-015-1550-0

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Effect of anti-RANKL mAb in skeleton. Representative reconstructed images of longitudinal and crosssectional femoral microCT data (a). Bone volume fraction (BV/TV) and trabecular bone mineral density (Tb.BMD) were significantly higher in the mAb than VC group (b and c). Significantly higher trabecular numbers (Tb.N) (d) and trabecular thickness (Tb.Th) (e) and significantly lower trabecular separation (Tb.Sp) (f) were found in the mAb group vs. VC. Representative photomicrographs of TRAP-stained bone sections. Scale bar 50 μm (g). Asterisk indicates osteoclasts on the bone surface and arrowheads TRAP(+) MNCs in bone marrow. Osteoclast surface (OC.S/BS) (h) and osteoclast numbers (OC.N/BS) were significantly lower in the mAb group than control (i). The numbers of TRAP(+) mononuclear cells (MNCs) were significantly higher in the mAb group than control (j). n ≥ 7/ group; *p < 0.05, **p < 0.01, ***p < 0.001