Table 1.
In vitro micronucleus test results in human lymphocytes following treatment with flubendazole after short (3h) exposure
| Treatment | Flubendazole (µg/ml) | Cytotoxicity (%) | Mean MNBN cell frequency (%) |
|---|---|---|---|
| 3+21h –S9 | 0.0 (Vehicle) | 0.0 | 0.23 |
| 2.0 | 0.0 | 0.05 | |
| 5.0 | 7.0 | 0.55* | |
| 6.0 | 0.0 | 0.85* | |
| 7.5 | 8.0 | 1.65* | |
| 9.0 | 26.0 | 6.55* | |
| MMC (0.80) | – | 8.70* | |
| 3+21h +S9 | 0.0 (Vehicle) | 0.0 | 0.25 |
| 10.0 | 0.0 | 0.25 | |
| 12.0 | 0.0 | 0.20 | |
| 14.0 | 14.0 | 0.65* | |
| 16.0 | 4.0 | 0.90* | |
| 19.0 | 7.0 | 0.55* | |
| 25.0 | 12.0 | 2.88* | |
| CYC (12.5) | – | 1.40* |
Historical control range for the testing laboratory was 0.1–0.95 and 0–1.1 for –S9 and +S9, respectively. MMC, mitomycin C; CYC, cyclophosphamide.
*Statistically significant.