Table 3.
Mechanistic study in vitro, to show the percentage of micronuclei with and without centromeres, to determine aneugenicity or clastogenicity, respectively
| Compound | Concentration μg/ml | Fold increases in MN over concurrent vehicle control | % micronuclei with a centromere | % micronuclei without a centromere | Total MN cells scored |
|---|---|---|---|---|---|
| Flubendazole (3h + 21h, −S9) | 7.5 | 7.2 | 80 | 20 | 100 |
| 9.0 | 28.5 | 88 | 12 | 100 | |
| Flubendazole (3h + 21h, +S9) | 16 | 3.6 | 83 | 17 | 100 |
| 25 | 11.5 | 86 | 14 | 100 | |
| Cyclophosphamide | 12.5 | 5.6 | 16 | 84 | 100 |
| Vinblastine | 0.12 | 56.6 | 73 | 11 | 84 |