Table 6.
In vitro micronucleus test of R-reduced flubendazole (combined data from two experiments)
| Concentration (µg/ml) | Cytotoxicity (%) | Frequency of microncucleated binucleate cells (%)* |
|---|---|---|
| 0.0 | 0.0 | 0.30a/0.65 |
| 1.1a | 10.0 | 0.85 |
| 3.2a | 18.0 | 2.25 |
| 8.8a | 3.0 | 2.75 |
| 10.0 | 0.0 | 5.05 |
| 20.0 | 0.0 | 4.50 |
| 24.5a | 3.0 | 2.75 |
| 35.0 | 17.0 | 3.95 |
| 40.0 | 22.0 | 3.75 |
| 45.0 | 15.0 | 2.90 |
aData from Experiment 1, all other data is from Experiment 2.
*All treated groups gave increases in micronucleated binucleate cells that were statistically significant relative to the vehicle control P < 0.05.