Table 9.
Mechanistic study to determine the nature (aneugenic vs. clastogenic) of the micronuclei from the in vitro micronucleus test of the reduced flubendazole enantiomers (R and S)
| Compound | Concentration (µg/ml) | Fold increases in MN over concurrent vehicle control | %C+ micronuclei | %C− micronuclei | Total MN cells scored |
|---|---|---|---|---|---|
| R-reduced flubendazole (RRF) | 3.2 | 7.5 | 40 | 60 | 100 |
| RRF | 8.8 | 9.2 | 57 | 43 | 82 |
| RRF | 24.5 | 14.7 | 49 | 51 | 57 |
| S-reduced flubendazole (SRF) | 4.2 | 2.2 | 39 | 61 | 100 |
| SRF | 11.7 | 6.7 | 33 | 67 | 100 |
| SRF | 32.4 | 9.5 | 37 | 63 | 67 |
| Albendazole | 0.7 | 9.3 | 72 | 28 | 100 |
| Albendazole sulfoxide | 30.0 | 6.2 | 71 | 29 | 100 |
| Flubendazole | 2.0 | 7.1 | 70 | 30 | 100 |
| Mitomycin C | 0.1 | 35 | 7 | 93 | 100 |