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. 2015 Oct 6;31(3):309–321. doi: 10.1093/mutage/gev070

Table 9.

Mechanistic study to determine the nature (aneugenic vs. clastogenic) of the micronuclei from the in vitro micronucleus test of the reduced flubendazole enantiomers (R and S)

Compound Concentration (µg/ml) Fold increases in MN over concurrent vehicle control %C+ micronuclei %C− micronuclei Total MN cells scored
R-reduced flubendazole (RRF) 3.2 7.5 40 60 100
RRF 8.8 9.2 57 43 82
RRF 24.5 14.7 49 51 57
S-reduced flubendazole (SRF) 4.2 2.2 39 61 100
SRF 11.7 6.7 33 67 100
SRF 32.4 9.5 37 63 67
Albendazole 0.7 9.3 72 28 100
Albendazole sulfoxide 30.0 6.2 71 29 100
Flubendazole 2.0 7.1 70 30 100
Mitomycin C 0.1 35 7 93 100