FIGURE 8.

Depletion of Tregs changes hepatic mRNA levels of SOCS signaling and Notch signaling. The mice were administered with purified anti-mouse CD25 antibody (200 μg/mouse; i.p.) 48 h before the TP administration, then underwent TP administration (500 μg/kg; i.g.) and sacrificed 24 h after TP administration. Relative expressions of SOCS signaling (A–C), Notch signaling (D–L) were measured by real-time RT-PCR and normalized to GAPDH mRNA. The data are shown as the mean ± SEM of six mice. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 vs. control. ^#P < 0.05 and ^###P < 0.001 vs. TP group.