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Suppression of orthotopic growth of H1650-Luc cells by BO-1978 alone or in combination with gefitinib. H1650-Luc cells (2 × 106) were intrathoracically implanted in the left lobes of nude mice. On day 2, the mice were treated with BO-1978 alone or in combination with gefitinib, as described in Figure 6. Tumor growth was monitored by IVIS. (A) Representative images of tumor growth; (B) averaged photon intensity; and (C) body weight.
