Table 1.
Characteristics of the NSCLC Lines Used in This Study.
| Cell Line | EGFR | TP53 | Kras | TKI Susceptibility |
|---|---|---|---|---|
| H460 | Wild-type | Wild-type | Q61H | Intrinsic resistance |
| A549 | Wild-type | Wild-type | G12S | Intrinsic resistance |
| H1299 | Wild-type | Deficient | Wild-type | Intrinsic resistance |
| CL141T | Wild-type | R248W | Wild-type | Intrinsic resistance |
| CL100 | Exon 19 deletion | ND | Wild-type | Sensitive |
| H1650 | Exon 19 deletion | Wild-type | Wild-type | Resistance (Pten loss) |
| H1975 | L858R/T790M | Wild-type | Wild-type | Acquired resistance |
| CL97 | G719A/T790M | R273H | Wild-type | Acquired resistance |
| CL1-5 | Wild-type | R248W | Wild-type | Intrinsic resistance |
| PC9 | Exon 19 deletion | Wild-type | Wild-type | Sensitive |
| PC9/gef B4 | Exon 19 deletion | Wild-type | Wild-type | Acquired resistance (Slug overexpression) |
ND, not determined.