Table 3.
IC50 Values (μM) of BO-1978 in Multiple Drug–Resistant and Cisplatin-Resistant Cells.⁎
| Cell Line | BO-1978 | Vincristine (nM) | Doxorubicin | Cisplatin |
|---|---|---|---|---|
| CCRF-CEM | 0.46 ± 0.12 | 2.23 ± 0.19 | ND | ND |
| CCRF/VBL | 0.41 ± 0.03 [0.78x]† | 2128 ± 248.86 [954.3x] | ND | ND |
| KB | 1.96 ± 0.39 | 2.16 ± 0.25 | ND | ND |
| KB/vin10 | 1.56 ± 0.51 [0.79x] | 510 ± 170 [236.1x] | ND | ND |
| MES-SA | 0.77 ± 0.08 | ND | 0.038 ± 0.003 | 1.82 ± 0.66 |
| MES-SA/dx5 | 0.47 ± 0.12 [0.61x] | ND | 2.30 ± 0.98 [60.52x] | 2.27 ± 0.73 [1.25x] |
| NTUB1 | 1.14 ± 0.32 | ND | ND | 2.97 ± 1.43 |
| NTUB1/P | 1.92 ± 0.39 [1.68x] | ND | ND | 62.09 ± 15.30 [20.9x] |
⁎
IC50, the concentration of drug required to inhibit cell growth by 50% (mean ± S.D. of three independent experiments).
†
Numbers in brackets are resistance factors.