Fig. 2.

Acute β-adrenergic response assessed via echocardiography.

(A) Representative 1-dimensional echocardiographic long-axis projections of pre (left panel) and post (right panel) i.p. single bolus vehicle (upper row) or DOB injection (lower row) and corresponding average heart rates.

Changes induced by acute i.p. DOB injection in male wildtype mice in regional dimension of (B) IVS, (C) LVAW and (D) LVPW, (E) LVID and (F) LV volume in end-diastole and end-systole and in (G) LV performance, as assessed by EF, FS and (H) heart rate (displayed as delta and total values). Vehicle-injected mice served as control. Animal numbers per treatment n = 4; values are shown as mean ± SE, *p < 0.05 vs. vehicle; unpaired student's t-test.