Fig. 6.

Morphological evidence for moderate LV hypertrophy induced by sustained (14-day) β-AR stimulation in the absence of myocardial fibrosis.

Effect of continuous 14-days s.c. ISO infusion in male wildtype mice on (A) body weight, (B) heart weight as assessed by gravimetric analyses, (C) cardiomyocyte cross-sectional area and (D) percentage LV collagen content, as assessed via histological analyses. Saline-infused mice served as control. Animal numbers per treatment n = 8 if not indicated otherwise; values are shown as mean ± SE, *p < 0.05 vs. Control; unpaired student's t-test.