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. 2016 Apr 22;6:24937. doi: 10.1038/srep24937

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Representative images showing carcinoma, paracancerous tissue and paired normal tissue in liver (A,B), stomach (C) and colon (D). Paracancerous tissue was defined as the tissue less than 2 cm away from the tumor edge. Paired normal tissue was defined as the tissue more than 2 cm away from the tumor edge.