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. 2016 Apr 22;6:24977. doi: 10.1038/srep24977

Figure 2. Hepatic levels of NAD+ and the main NAD+ precursors in healthy rats supplemented with different doses of PACs.

Figure 2

(A–B) PAC consumption increased the hepatic NAD+ (A) and Nam (B) levels in a dose-dependent manner. (C) Similarly, the Trp, Na and NMN concentrations were also significantly increased in animals supplemented with 50 mg of PACs/kg bw compared to the control rats. The animals were fed a standard chow diet supplemented with 0 (control group), 5, 25 or 50 mg of PACs/kg bw for 21 days. The values shown are the means ± SE of 10 animals per group. The letters denote a significant difference between groups (P < 0.05; one-way ANOVA and LSD post-hoc test comparison). Na: nicotinic acid; NAD+: nicotinamide adenosine dinucleotide; Nam: nicotinamide; NMN: nicotinamide mononucleotide; PACs: proanthocyanidins; Trp: tryptophan.