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. Author manuscript; available in PMC: 2017 Apr 20.
Published in final edited form as: Neuron. 2016 Apr 20;90(2):417–422. doi: 10.1016/j.neuron.2016.03.009

Figure 1. Aβ43 production is reduced in L435F KI/+ brains and undetectable in C410Y KI/KI brains.

Figure 1

(A) ELISA measurements of Aβ43 following in vitro γ-secretase assay in L435F KI mice at 3 months of age. De novo production of Aβ43 in cortical homogenates is reduced in L435F KI/+ mice relative to littermate Psen1+/+ controls (**p<0.005). (B) ELISA measurements of Aβ43 following in vitro γ-secretase assay in C410Y KI mice at embryonic day 18.5 (E18.5). Relative to littermate Psen1+/+ controls, de novo production of Aβ43 in brain homogenates is reduced in C410Y KI/+ mice and undetectable in C410Y KI/KI mice (***p<0.001). All data are presented as mean ± SEM.