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. 2016 Jan 22;5:11–13. doi: 10.1016/j.lrr.2016.01.001

Table 1.

Treatment history and outcome prior to combination of As2O3 and tamibarotene.

Phase of treatment Drugs Result of treatment
At initial diagnosis
First induction therapy ATRA, Ara-C, and IDA hCR
Post-remission therapy 1 Ara-C and MIT hCR
Post-remission therapy 2 Ara-C and DNR hCR
Post-remission therapy 3 Ara-C and IDA mCR
Maintenance therapy ATRA Molecular relapse
At first molecular relapse
Re-induction therapy 1 Tamibarotene hCR
Re-induction therapy 2 As2O3 hCR
Post-remission therapy 1 As2O3 hCR
Post-remission therapy 2 As2O3 hCR
Post-remission therapy 3 high-dose Ara-C mCR
aPBSCT Bu and MEL mCR
At second molecular relapse
Re-induction therapy Tamibarotene Hematological relapse

ATRA: all-trans retinoic acid, Ara-C: cytarabine, IDA: idarubicin, hCR: hematological complete remission, MIT: mitoxantrone, DNR: daunorubicin, mCR: molecular complete remission, aPBSCT: autologous peripheral blood stem cell transplantation, Bu: busulfan, MEL: melphalan.