Table 1.
Treatment history and outcome prior to combination of As2O3 and tamibarotene.
| Phase of treatment | Drugs | Result of treatment |
|---|---|---|
| At initial diagnosis | ||
| First induction therapy | ATRA, Ara-C, and IDA | hCR |
| Post-remission therapy 1 | Ara-C and MIT | hCR |
| Post-remission therapy 2 | Ara-C and DNR | hCR |
| Post-remission therapy 3 | Ara-C and IDA | mCR |
| Maintenance therapy | ATRA | Molecular relapse |
| At first molecular relapse | ||
| Re-induction therapy 1 | Tamibarotene | hCR |
| Re-induction therapy 2 | As2O3 | hCR |
| Post-remission therapy 1 | As2O3 | hCR |
| Post-remission therapy 2 | As2O3 | hCR |
| Post-remission therapy 3 | high-dose Ara-C | mCR |
| aPBSCT | Bu and MEL | mCR |
| At second molecular relapse | ||
| Re-induction therapy | Tamibarotene | Hematological relapse |
ATRA: all-trans retinoic acid, Ara-C: cytarabine, IDA: idarubicin, hCR: hematological complete remission, MIT: mitoxantrone, DNR: daunorubicin, mCR: molecular complete remission, aPBSCT: autologous peripheral blood stem cell transplantation, Bu: busulfan, MEL: melphalan.