Table 2. Interactions between proteins of S. pneumoniae and its phage Dp-1.
| Phage protein | Host protein | 3AT | LIR | ||
|---|---|---|---|---|---|
| orf4 | Queuosine biosynth. protein QueE | SP_2036 | PTS system, IIA component | 25 | 454 |
| orf9 | No similarity | SP_1504 | TPR domain protein | 0.5 | 19 |
| orf9 | No similarity | SP_0259 | Holliday junction DNA helicase RuvB | 50 | 11 |
| orf9 | No similarity | SP_1395 | putative phosphate transport system regulatory protein PhoU | 50 | 23 |
| orf9 | No similarity | SP_2168 | putative fucose operon repressor | 50 | 15 |
| orf12 | Holliday junction resolvase RecU | SP_2168 | putative fucose operon repressor | 0.1 | 2 |
| orf14 | dUTPase | SP_2125 | conserved hypothetical protein | 50 | 45 |
| orf16 | NAD-dependent DNA ligase | SP_0259 | Holliday junction DNA helicase RuvB | 50 | 5 |
| orf18 | DNA polymerase III, delta’ subunit HolB | SP_1584 | GTP-sensing transcriptional pleiotropic repressor CodY | 24.5 | 6 |
| orf29 | Hypothetical protein | SP_2012 | glyceraldehyde 3-phosphate dehydrogenase | 0.25 | 3 |
| orf31 | Hypothetical protein | SP_2168 | putative fucose operon repressor | 0.2 | 5 |
| orf31 | Hypothetical protein | SP_1153 | hypothetical protein | 0.25 | 6 |
| orf31 | Hypothetical protein | SP_0259 | Holliday junction DNA helicase RuvB | 0.5 | 4 |
| orf32 | Hypothetical protein | SP_0194 | conserved hypothetical protein | 47.5 | 5 |
| orf32 | Hypothetical protein | SP_0259 | Holliday junction DNA helicase RuvB | 47.5 | 3 |
| orf32 | Hypothetical protein | SP_1540 | single-strand binding protein Ssb | 47.5 | 3 |
| orf32 | Hypothetical protein | SP_1669 | MutT/nudix family protein | 47.5 | 10 |
| orf32 | Hypothetical protein | SP_1915 | hypothetical protein | 47.5 | 5 |
| orf33 | Hypothetical protein | SP_1088 | DNA repair protein RadC | 0.5 | 3 |
| orf34 | Hypothetical protein | SP_2157 | alcohol dehydrogenase, iron-containing | 2 | 35 |
| orf34 | Hypothetical protein | SP_0446 | acetolactate synthase, small subunit | 9 | 12 |
| orf39 | Zinc finger protein | SP_0259 | Holliday junction DNA helicase RuvB | 50 | 10 |
| orf44 | Rho-like domain lipoprotein | SP_1725 | sucrose operon repressor | 2.25 | 3 |
| orf44 | Rho-like domain lipoprotein | SP_2157 | alcohol dehydrogenase, iron-containing | 2.25 | 13 |
| orf44 | Rho-like domain lipoprotein | SP_1050 | putative transcriptional regulator | 4.75 | 2 |
| orf44 | Rho-like domain lipoprotein | SP_1536 | conserved hypothetical protein | 4.75 | 10 |
| orf44 | Rho-like domain lipoprotein | SP_0446 | acetolactate synthase, small subunit | 9.75 | 6 |
| orf44 | Rho-like domain lipoprotein | SP_1575 | conserved hypothetical protein | 9.75 | 14 |
| orf47 | Hypothetical protein | SP_0687 | ABC transporter, ATP-binding protein | 49 | 4 |
| orf48 | Hypothetical protein | SP_2168 | putative fucose operon repressor | 0.5 | 3 |
| orf48 | Hypothetical protein | SP_1746 | conserved hypothetical protein | 2.5 | 3 |
| orf51 | Hypothetical protein | SP_1672 | recombination protein RecR | 0.5 | 6 |
| orf58 | Holin | SP_1505 | membrane protein | 1 | 1 |
| orf58 | Holin | SP_1731 | conserved hypothetical protein | 2.5 | 3 |
| orf58 | Holin | SP_1606 | glycosyl transferase, family 2 | 25 | 3 |
| orf58 | Holin | SP_1751 | putative transporter, CorA family | 25 | 5 |
| orf60 | Hypothetical protein | SP_2024 | PTS system, IIA component | 10 | 5 |
| orf72 | Membrane protein | SP_1606 | glycosyl transferase, family 2 | 50 | 50 |
Host proteins are given as locus numbers. 3AT is the highest 3-AT concentration at which this interaction was detected. LIR are luminescence intensity ratios from LuMPIS assays rounded to the nearest integer (see text for details). Combinations of high 3AT score and LIR values are most reliable.