Table 2.

Distinct features ANOVA showing independent effects of BD and MDD illness

		Talairach coordinates
Contrast/lobe	BA	x	y	z	Z	mm3	Factor
Diagnostic group effect
Frontal
Middle frontal	8	32	16	41	4.16	2840	Group 1
Medial frontal	9	15	41	16	3.46	1144	Group 1
Dorsal cingulate*	24	8	−19	39	4.38	10120	Group 3
Dorsal anterior cingulate	32	−14	20	41	3.76	2472	Group 1
Parietal
Precuneus*	7	10	−62	51	4.11	1064	Group 2
*	7	−15	−63	39	3.2	472	Group 3
*	7	23	−65	30	3.14	640	Group 2
Posterior cingulate*	31	31	−63	16	3.73	1472	Group 1
Temporal
Middle temporal	21	−38	−13	−8	4.08	1608	Group 3
Insula	13	−42	−7	15	3.72	1056	Group 3
Occipital
Cuneus*	18	−18	−81	25	4.16	14712	Group 1
	18	13	−93	18	3.31	552	Group 1
Subcortical
Declive*		13	−58	−14	3.75	600	Group 3

Group 1 = MDD hyper > HC > BD hypo.

Group 2 = BD hyper > MDD > HC hypo.

Group 3 = MDD hyper, HC and BD Hypo.

*Overlaps significantly with the task positive ‘Go’ network (Supplementary Fig. 1). BA = Brodmann area.