Table 3.
Prevalence of medical history of systemic connective tissue features in female FMD cohort compared to historical control data as available.
| Categorical Variable | FMD patients number/total assessed* | % FMD patients with feature | %Historical Controls (Reference) | Available Control Population |
|---|---|---|---|---|
| Nearsightedness | 95/138 | 68.8% | 34.2%(17) 28.1%(18) |
German female (n=6,897) age 35–74 years American females (n=2354) age 40–84 years |
| Diopters < −3 | 37/127 | 29.1% | -- | |
| Dental crowding | 41/138 | 29.7% | 7.1–59.2%(19) | Caucasian children age 3.5–16 years |
| Scoliosis | 37/137 | 27.0% | 36%(24) | American females age 50–84 |
| Early onset osteoarthritis | 21/135 | 15.6% | 5.20%(25) | American females 25–74 years, cumulative prevalence for 25–54 years with knee OA |
| Hernia | 13/139 | 9.4% | -- | |
| Joint dislocation | 17/139 | 12.2% | -- | |
| Without obvious trauma | 8/17 | 5.7%† | -- | |
| Ever broken bone | 76/139 | 54.7% | -- | |
| Without obvious trauma | 8/76 | 5.7%† | -- | |
| Transfusion peripartum | 4/117 | 3.4% | 1.4%(26) 1.0%(27) |
Premenopausal American females N=10,134 N=59,282 |
| Spontaneous pneumothorax | 3/138 | 2.2% | -- | |
| Club foot | 0/139 | 0.0% | 1–2/1000(20) | US Live Births 1999–2004 |
| Cleft Palate | 0/139 | 0.0% | 6.28%(20) | US Live Births 1999–2004 |
*
Denominator reflects total number assessed. Data was excluded if subjects were unsure of clinical history or unable to perform physical maneuvers
†
Percent of the total cohort