Table 4.
Prevalence of systemic connective tissue features on physical examination in female FMD cohort compared to historical control data as available.
| Categorical Variable | FMD patients number/total assessed* | % FMD patients with feature | %Historical Controls (Reference) | Available Control Population |
|---|---|---|---|---|
| High palate | 46/139 | 33.1% | -- | |
| Tori palatinus | 26/139 | 18.7% | 22.8% (white)(15) 12.2 (black)(15) |
Skull analysis of Modern Americans, n=328 |
| Tori mandibularis | 28/139 | 20.1% | 38.8% (white)(15) 24.8 (black)(15) |
Skull analysis of Modern Americans, n=328 |
| Wrist and Thumb sign | 9/139 | 6.5% | -- | |
| Wrist sign | 24/139 | 17.3% | -- | |
| Thumb sign | 10/138 | 7.2% | -- | |
| Dystrophic scarring | 24/139 | 17.3% | -- | |
| Keloid | 13/139 | 9.4% | -- | |
| Atrophic | 15/139 | 10.8% | -- | |
| Skin striae | 8/139 | 5.8% | -- | |
| Pes Planus | 18/139 | 12.9% | 8%(16) 16.3% (white)(28) 38.3% (black)(28) |
Framingham Foot Substudy Cohort (n=2.089) 55% Female, mean age 65 years American cohort (n=1691), mean age 69 years, 68% Female, 31% African American |
| Hindfoot deformity | 13/138 | 9.4% | -- | |
| Pectus | 10/139 | 7.2% | ||
| Pectus excavatum | 5/139 | 3.6% | 1/1000(21) | Newborn cohort (n=52,000) 45% white, 47% black |
| Pectus carinatum | 5/139 | 3.6% | 1/1500(21) | Newborn cohort (n=52,000) 45% white, 47% black |
| Uvula abnormality | 1/139 | 0.7% | -- |
*
Denominator reflects total number assessed. Data was excluded if subjects were unsure of clinical history or unable to perform physical maneuvers