Table 5.
Comparison of 20 select connective tissue physical features in female FMD cohort by vascular risk profile
| Connective Tissue Finding | number/total* (%), n=139 | High risk †, n=51 | Standard Risk, n=88 | p-value |
|---|---|---|---|---|
| Nontraumatic joint dislocation | 8/138 (5.8) | 3/50 (6.0) | 5/88 (5.7) | 0.294 |
| Nontraumatic fracture | 8/137 (5.8) | 1/49 (2.0) | 7/88 (8.0) | 0.258 |
| Early onset osteoarthritis | 21/135 (15.6) | 5/49 (10.2) | 16/86 (18.6) | 0.200 |
| Hernia | 13/139 (9.4) | 6/51 (11.8) | 7/88 (8.0) | 0.549 |
| Scoliosis | 37/137 (27.0) | 10/50 (20.0) | 27/87 (31.0) | 0.334 |
| Club foot | 0 (0) | 0 (0) | 0 (0) | -- |
| Cleft palate | 0 (0) | 0 (0) | 0 (0) | -- |
| Nearsightedness >−3 diopters | 37/127 (29.1) | 12/46 (26.1) | 25/81 (30.9) | 0.569 |
| Spontaneous pneumothorax | 3/138 (2.2) | 3/51 (5.9) | 0/87 (0) | 0.049 |
| Peripartum blood transfusion | 4/117 (3.4) | 1/43 (2.3) | 3/74 (4.1) | 1.000 |
| Dental crowding | 41/138 (29.7) | 13/50 (26.0) | 28/88 (31.8) | 0.318 |
| Beighton ≥5/9 | 4/139 (2.9) | 3/51 (5.9) | 1/88 (1.1) | 0.140 |
| Wrist and Thumb sign | 9/139 (6.5) | 4/51 (7.8) | 5/88 (5.7) | 0.725 |
| Pectus deformity | 10/139 (7.2) | 4/51 (7.8) | 6/88 (6.8) | 1.000 |
| Dystrophic scarring | 24/139 (17.3) | 11/51 (21.6) | 13/88 (14.8) | 0.307 |
| Atrophic scarring | 15/139(10.8) | 9/51 (17.6) | 6/88 (6.8) | 0.047 |
| Keloid scarring | 13/139 (9.4) | 4/51 (7.8) | 9/88 (10.2) | 0.768 |
| Hypertelorism | 0 (0) | 0 (0) | 0 (0) | -- |
| High Palate | 46/139 (33.1) | 22/51 (43.1) | 24/88 (27.3) | 0.055 |
| Uvula abnormality | 1/139 (0.7) | 0/51 (0) | 1/88 (1.1) | 1.000 |
| Pes planus and/or hindfoot deformity | 26/139 (18.7) | 11/51 (21.6) | 15/88 (17.0) | 0.510 |
| Skin striae | 8/139 (5.8) | 2/51 (3.9) | 6/88 (6.8) | 0.710 |
*
Denominator reflects total number assessed. Data was excluded if subjects were unsure of clinical history or unable to perform physical maneuvers
†
High risk defined as ≥1 arterial dissection and/or ≥2 arterial aneurysms