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. 2016 Mar 21;11(5):3009–3014. doi: 10.3892/ol.2016.4358

Table I.

GO terms most frequently enriched by upregulated and downregulated DEGs in head and neck squamous cell carcinoma.

Category Term Counta P-value FDR
Upregulated DEGs
  GOTERM_BP GO:0007155~cell adhesion 42 4.92E-17 8.08E-14
  GOTERM_BP GO:0022610~biological adhesion 42 5.18E-17 8.50E-14
  GOTERM_BP GO:0030198~extracellular matrix organization 17 2.12E-13 3.48E-10
  GOTERM_BP GO:0043062~extracellular structure organization 19 2.20E-12 3.62E-09
  GOTERM_BP GO:0032963~collagen metabolic process 10 3.75E-11 6.15E-08
  GOTERM_CC GO:0005578~proteinaceous extracellular matrix 40 1.88E-26 2.48E-23
  GOTERM_CC GO:0031012~extracellular matrix 40 3.23E-25 4.27E-22
  GOTERM_CC GO:0044420~extracellular matrix part 25 5.83E-22 7.70E-19
  GOTERM_CC GO:0044421~extracellular region part 56 4.52E-21 5.97E-18
  GOTERM_CC GO:0005581~collagen 14 3.91E-16 5.88E-13
  GOTERM_MF GO:0005201~extracellular matrix structural constituent 15 3.11E-12 4.32E-09
  GOTERM_MF GO:0050840~extracellular matrix binding   8 3.24E-08 4.50E-05
  GOTERM_MF GO:0005198~structural molecule activity 27 9.82E-08 1.36E-04
  GOTERM_MF GO:0005509~calcium ion binding 32 4.02E-07 5.58E-04
  GOTERM_MF GO:0005518~collagen binding   7 5.28E-06 7.33E-03
Downregulated DEGs
  GOTERM_BP GO:0008544~epidermis development 20 1.27E-11 2.11E-08
  GOTERM_BP GO:0007398~ectoderm development 20 5.04E-11 8.39E-08
  GOTERM_BP GO:0009913~epidermal cell differentiation 13 3.26E-10 5.42E-07
  GOTERM_BP GO:0030855~epithelial cell differentiation 15 8.05E-09 1.34E-05
  GOTERM_BP GO:0030216~keratinocyte differentiation 11 2.64E-08 4.40E-05
  GOTERM_CC GO:0001533~cornified envelope   9 3.27E-10 4.24E-07
  GOTERM_MF GO:0005198~structural molecule activity 26 5.36E-06 7.55E-03
a

Enriched gene number in the GO category. GO, Gene Ontology; DEGs, differentially expressed genes; BP, biological process; CC, cellular component; MF, molecular function; FDR, false discovery rate.