Table I.
GO terms most frequently enriched by upregulated and downregulated DEGs in head and neck squamous cell carcinoma.
| Category | Term | Counta | P-value | FDR |
|---|---|---|---|---|
| Upregulated DEGs | ||||
| GOTERM_BP | GO:0007155~cell adhesion | 42 | 4.92E-17 | 8.08E-14 |
| GOTERM_BP | GO:0022610~biological adhesion | 42 | 5.18E-17 | 8.50E-14 |
| GOTERM_BP | GO:0030198~extracellular matrix organization | 17 | 2.12E-13 | 3.48E-10 |
| GOTERM_BP | GO:0043062~extracellular structure organization | 19 | 2.20E-12 | 3.62E-09 |
| GOTERM_BP | GO:0032963~collagen metabolic process | 10 | 3.75E-11 | 6.15E-08 |
| GOTERM_CC | GO:0005578~proteinaceous extracellular matrix | 40 | 1.88E-26 | 2.48E-23 |
| GOTERM_CC | GO:0031012~extracellular matrix | 40 | 3.23E-25 | 4.27E-22 |
| GOTERM_CC | GO:0044420~extracellular matrix part | 25 | 5.83E-22 | 7.70E-19 |
| GOTERM_CC | GO:0044421~extracellular region part | 56 | 4.52E-21 | 5.97E-18 |
| GOTERM_CC | GO:0005581~collagen | 14 | 3.91E-16 | 5.88E-13 |
| GOTERM_MF | GO:0005201~extracellular matrix structural constituent | 15 | 3.11E-12 | 4.32E-09 |
| GOTERM_MF | GO:0050840~extracellular matrix binding | 8 | 3.24E-08 | 4.50E-05 |
| GOTERM_MF | GO:0005198~structural molecule activity | 27 | 9.82E-08 | 1.36E-04 |
| GOTERM_MF | GO:0005509~calcium ion binding | 32 | 4.02E-07 | 5.58E-04 |
| GOTERM_MF | GO:0005518~collagen binding | 7 | 5.28E-06 | 7.33E-03 |
| Downregulated DEGs | ||||
| GOTERM_BP | GO:0008544~epidermis development | 20 | 1.27E-11 | 2.11E-08 |
| GOTERM_BP | GO:0007398~ectoderm development | 20 | 5.04E-11 | 8.39E-08 |
| GOTERM_BP | GO:0009913~epidermal cell differentiation | 13 | 3.26E-10 | 5.42E-07 |
| GOTERM_BP | GO:0030855~epithelial cell differentiation | 15 | 8.05E-09 | 1.34E-05 |
| GOTERM_BP | GO:0030216~keratinocyte differentiation | 11 | 2.64E-08 | 4.40E-05 |
| GOTERM_CC | GO:0001533~cornified envelope | 9 | 3.27E-10 | 4.24E-07 |
| GOTERM_MF | GO:0005198~structural molecule activity | 26 | 5.36E-06 | 7.55E-03 |
a
Enriched gene number in the GO category. GO, Gene Ontology; DEGs, differentially expressed genes; BP, biological process; CC, cellular component; MF, molecular function; FDR, false discovery rate.