Table II.
KEGG pathway enrichment analysis of upregulated and downregulated differentially expressed genes.
| KEGG pathway term | Counta | Genes | P-value | FDR |
|---|---|---|---|---|
| Upregulated genes | ||||
| ECM-receptor interaction | 23 | COL1A1, COL4A1, TNC | 1.24E-20 | 1.35E-17 |
| Focal adhesion | 26 | FN1, EGFR, COL1A1 | 4.22E-15 | 4.59E-12 |
| Small cell lung cancer | 11 | FN1, CKS1B, LAMB3, COL4A2 | 2.11E-06 | 0.00229 |
| Downregulated genes | ||||
| Drug metabolism | 9 | CYP3A5, CYP2C18, FMO2, MAOB | 6.49E-06 | 0.0071 |
a
Enriched gene number in the KEGG pathway term. KEGG, Kyoto Encyclopedia of Genes and Genomes; FDR, false discovery rate; ECM, extracellular matrix; COLA, collagen type alpha; TNC, tenascin C; FN1, fibronectin 1; EGFR, epidermal growth factor receptor; CKS1B, cyclin-dependent kinases regulatory subunit 1; LAMB3, laminin, beta 3; CYP, cytochrome P450; FMO, flavin containing monooxygenase 2; MAOB, monoamine oxidase B.