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. 2016 Mar 22;6(4):e00449. doi: 10.1002/brb3.449

Figure 3.

Figure 3

G1 and β‐estradiol were able to reduce the secretion of IL‐1β and TNF‐α in primary microglia culture. (A) LPS‐induced IL‐1β secretion was suppressed by β‐estradiol (n = 10, P = 0.0017, one‐way ANOVA and post hoc test, same as below) and G1 (n = 10, P < 0.0001). G15 abolished the inhibitory effect of β‐estradiol (n = 10, P = 0.4973). (B) LPS‐induced TNF‐α secretion was suppressed by β‐estradiol (n = 10, P < 0.0001) and G1 (n = 10, P < 0.0001). G15 abolished the inhibitory effect of β‐estradiol (n = 10, P = 0.1627). Data were presented as mean + SD. **P < 0.01, ****P < 0.0001.