Figure 1.

Effects of Imiquimod and TLR7 ligand alone or in combination on HCC cell proliferation were detected by MTT assay. (A) Imiquimod (100 µM) was demonstrated to exert effective repression on cell proliferation of the HCCLM3 and MHCC97-H HCC cell lines following 48 h of incubation, *P<0.01. (B) TLR7 ligand (100 nM) significantly induced cell proliferation, *P<0.01. (C) A dose of 100 µM Imiquimod effectively reversed the oncogenic effect of the TLR7 ligand, compared with each of the drugs alone at 48 h *P<0.01. HCC, hepatocellular carcinoma; TLR7, Toll-like receptor 7.