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Increased PAI-1 expression levels in the hippocampal and blood tissues in model mice. The mRNA expression levels of PAI-1 in the (A) hippocampus and (B) blood were determined by quantitative polymerase chain reaction. The protein expression levels of PAI-1 in the (C) hippocampus and (D) blood were detected using western blot analysis and enzyme-linked immunosorbent assay. *P<0.05, **P<0.01 vs. the control group. PAI-1, plasminogen activator inhibitor-1.
