Table III.
Histomorphological characteristics of the GIST series.
| Tumor site | |||||
|---|---|---|---|---|---|
| Characteristics | Esophagus | Stomach | Small intestine | Rectum | All sites |
| Growth patterna,b, n (%)c | |||||
| Luminal/intramural | 2 (100.0) | 107 (84.3) | 46 (68.7) | 5 (100.0) | 160 (79.6) |
| Extramural | 0 (100.0) | 20 (15.7) | 21 (31.3) | 0 (100.0) | 41 (20.4) |
| Histomorphological pattern, n (%)c | |||||
| Spindle-cell | 2 (100.0) | 72 (56.7) | 45 (67.2) | 4 (80.0) | 123 (61.2) |
| Epitheloid | 0 (0.0) | 29 (22.8) | 9 (13.4) | 1 (20.0) | 39 (19.4) |
| Mixed type | 0 (0.0) | 26 (20.5) | 13 (19.4) | 0 (0.0) | 39 (19.4) |
| Mitoses/50 HPFs, n (%)c | |||||
| Median (range) | 1 (1–1) | 3 (0–266) | 3 (0–117) | 2 (0–6) | 3 (0–266) |
| Mean ± SD | 1.00±1.0 | 7.83±24.10 | 12.76 ±23.6 | 2.60±2.4 | 9.27±23.6 |
| Mucosal infiltrationb, n (%)c | |||||
| Yes | 2 (100.0) | 85 (66.9) | 34 (50.7) | 5 (100.0) | 126 (62.7) |
| No | 0 (0.0) | 42 (33.1) | 33 (49.3) | 0 (0.0) | 75 (37.3) |
| Mucosal ulceration, n (%)c | |||||
| Yes | 2 (100.0) | 87 (68.5) | 43 (64.2) | 4 (80.0) | 136 (67.7) |
| No | 0 (0.0) | 40 (31.5) | 24 (35.8) | 1 (20.0) | 65 (32.3) |
| Nuclear pleomorphismb,d | |||||
| Median (range) | 0.5 (0–1.0) | 1.0 (0–2,5) | 1.5 (0–2,5) | 1.0 (0–1,5) | 1.0 (0–2,5) |
| Mean ± SD | 0.50±0.707 | 1.20±0.543 | 1.33±0.519 | 0.90±0.548 | 1.23±0.543 |
| Skeinoid fibers, n (%)c | |||||
| Yes | 1 (50.0) | 56 (44.1) | 39 (58.2) | 2 (40.0) | 98 (48.8) |
| No | 1 (50.0) | 71 (55.9) | 28 (41.8) | 3 (60.0) | 103 (51.2) |
| Tumor cell necrosisb, n (%)c | |||||
| Yes | 2 (100.0) | 42 (33.1) | 22 (32.8) | 4 (80.0) | 70 (34.8) |
| No | 0 (0.0) | 85 (66.9) | 45 (67.2) | 1 (20.0) | 131 (65.2) |
a
According to Agaimy et al (7).
b
Significant differences between GIST sub-localizations using χ2 test or analysis of variance.
c
Percentage per column, i.e., per tumor site.
d
0, no; 1, low; 2, moderate; and 3, strong. GIST, gastrointestinal stromal tumor; HPFs, high-power fields; SD, standard deviation.