Table V.
Assessments of recurrence, metastasis and survival by either BR or CR analyses.
| Recurrence | Metastasis | Survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables | BR or CR | Variable(s) | OR (95% CI) | n | Variable(s) | OR (95% CI) | n | Variable(s) | OR (95% CI) | n |
| Clinicopathological (n=10) | ||||||||||
| Age, intention of surgery, | BR | Localization | 3.523 | |||||||
| localization, margin | (1.204–10.314) | 2 | 0 | Multifocality | 8.402 | 1 | ||||
| status, grade (TNM), | Margin status | 5.486 | (0.903–78.144) | |||||||
| multifocality, gender, size, | (0.924–32.569) | |||||||||
| tumor status (TNM), | CR | Localization | 5.373 | 1.161 | ||||||
| type of surgery | (1.742–16.571) | 2 | Size | (0.982–1.374) | 1 | 0 | ||||
| Margin status | 5.132 | |||||||||
| (1.109–23.747) | ||||||||||
| Morphological (n=8) | ||||||||||
| Growth pattern, | BR | Growth | 6.043 | Mitoses/50 HPFs | 1.023 | |||||
| histomorphological | pattern | (1.255–29.098) | 1 | (0.996–1.050) | 2 | 0 | ||||
| pattern, mitoses/50 HPFs, | Growth pattern | 4.726 | ||||||||
| mucosal infiltration, | (1.223–18.253) | |||||||||
| mucosal ulceration, | CR | Growth | 13.715 | Growth pattern | 6.632 | |||||
| nuclear pleomorphism, | pattern | (2.556–73.605) | 1 | (0.974–45.158) | 1 | 0 | ||||
| skeinoid fibers, tumor | ||||||||||
| cell necrosis | ||||||||||
| Immunohistochemical (n=13) | ||||||||||
| Bcl-2, CD117 (C-kit), | BR | CD34 | 0.991 | Ki-67/mm2 | 1.002 | |||||
| CD34, CD44, desmin, | (0.983–0.999) | 1 | 0 | (1.000–1.004) | 1 | |||||
| DOG-1, Ki-67/mm2, | CD34 | 0.992 | ||||||||
| PDGFRα, PHH3, P16, | (0.984–1.000) | |||||||||
| P53, SMA, S-100 | CR | 0 | 0 | Ki-67/mm2 | 1.003 | |||||
| (1.001–1.004) | 1 | |||||||||
| Total (n=31) | BR/CR | 4/3 | 2/2 | 3/1 | ||||||
| Further risk classification of GIST cases based on predicted probabilities of margin status, localization, multifocality and growth pattern (see Fig.1 for Kaplan-Meier analyses). | ||||||||||
All analysed variables are listed and the bold print indicates statistical significance. In the column of recurrence, metastasis and survival, the variables identified via multivariate statistical analysis are listed and the bold print indicates OR ≥5.0. BR, binary logistic regression; CR, Cox regression; OR, odds ratio; CI, confidence interval; HPFs, high-power fields; Bcl-2, B-cell lymphoma 2; DOG-1, discovered on GIST 1; PDGFRα, platelet-derived growth factor receptor α; PHH3, phosphohistone H3; SMA, smooth muscle actin.