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. 2016 Mar 15;11(5):1678–1684. doi: 10.3892/etm.2016.3168

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Copyright: © De Ponte et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Hematoxilin and eosin staining of the rat mandibular bone and gingival epithelium following 30–45 days of zoledronate treatment (0.1 mg/kg). (A) Osteoblasts at the rim side of the cortical bone and empty osteocytic lacunae (magnification, ×10), as well as (B) Howship's lacunae (magnification, ×40) were observed. Hematoxylin and eosin staining also demonstrated the presence of (C) a detachment of the periodontal ligament from the bone (magnification, ×20), as well as (D) empty Volkman's and Haversian systems (magnification, ×20). (E) Normal gingival epithelium structure (magnification, ×20). HL, Howship's lacunae; PDL, periodontal ligament; V, Volkman's systems; H, Haversian systems.