Table II.
Summary of MLPA and iFISH results of TP53, ATM, BIRC3 and MALT1 in all studied cases.
| TP53 (%) | ATM (%) | BIRC3 (%) | MALT1 (%) | |||
|---|---|---|---|---|---|---|
| Case no. | MLPA | iFISH | MLPA | iFISH | iFISH | iFISH |
| A-1 | N | N | D | D (76.5) | D (75.0) | N |
| A-2 | n.a. | A (100.0) | n.a. | A (100.0) | A (100.0) | A (100.0) |
| A-3 | D | D (8.5) | N | N | N | N |
| A-4 | D | D (10.0) | N | N | N | N |
| A-5 | D | D (10.0) | N | N | N | N |
| A-6 to A-33 | N | N | N | N | N | N |
| A-34 to A-45 | n.a. | N | n.a. | N | N | N |
| C-1 | D | D (86.0) | D | D (11.0) | D (80.0) | N |
| C-2 | D | D (21.0) | N | D (23.0) | D (22.0) | N |
| C-3 | N | N | D | D (98.0) | D (90.0) | N |
| C-4 | N | N | D | D (23.5) | D (30.0) | N |
| C-5 | N | N | D | D (24.0) | D (25.0) | N |
| C-6 | N | N | D | D (88.0) | D (85.0) | N |
| C-7 | N | N | D | D (90.0) | D (80.0) | N |
| C-8 | N | N | D | D (77.0) | D (50.0) | N |
| C-9 | N | N | D | D (98.0) | D (75.0) | N |
| C-10 | N | N | D | D (87.0) | D (60.0) | N |
| C-11 | N | N | D | D (95.0) | D (90.0) | N |
| C-12 | N | N | D | D (83.0) | D (80.0) | N |
| C-13 | N | N | D | D (93.0) | D (25.0) | N |
| C-14 | N | N | N | D (33.0) | D (15.0) | N |
| C-15 | N | N | N | D (12.0) | D (13.0) | N |
| C-16 | n.a. | N | n.a. | D (80.0) | D (78.0) | N |
| C-17 | n.a. | N | n.a. | D (10.0) | D (9.0) | N |
| C-18 | n.a. | N | n.a. | D (73.0) | D (64.0) | N |
| C-19 | n.a. | N | n.a. | D (9.0) | D (10.0) | N |
| C-20 | n.a. | N | n.a. | D (96.0) | D (42.0) | N |
| C-21 | D | D (16.0) | N | A (50.0) | A (50.0) | A (50.0) |
| C-22 | D | D (40.0) | N | A (40.0) | A (40.0) | A (40.0) |
| C-23 | N | N | N | N | A (36.0) | N |
| C-24 | D | D (19.0) | N | N | N | N |
| C-25 | D | D (36.0) | N | N | N | N |
| C-26 | D | D (89.0) | N | N | N | N |
| C-27 | D | D (77.0) | N | N | N | N |
| C-28 | D | D (95.0) | N | N | N | N |
| C-29 | N | D (11.5) | N | N | N | N |
| C-30 | n.a. | D (86.5) | n.a. | N | N | N |
| C-31 | N | N | N | N | N | A (75.0) |
| C-32 to C-91 | N | N | N | N | N | N |
| C-92 to C-117 | n.a. | N | n.a. | N | N | N |
Data are expressed as type of change to copy number (% of cells with aberration). TP53, tumor protein 53; ATM, ataxia telangiectasia mutated; BIRC3, baculoviral IAP repeat-containing 3; MALT1, mucosa-associated lymphoid tissue lymphoma translocation gene 1; MLPA, multiplex ligation-dependent probe amplification; iFISH, interphase fluorescence in situ hybridization; A-, B-ALL case; C-, CLL case; N, no aberration; D, deletion; A, amplification; n.a., data not available.