FIG. 8.

In vivo bone reparation by implanting three different types of TIs for 7 weeks. (A) Schematic diagram of implanting TIs in mouse calvarial defects. (B) Bone reparation evaluated by micro-CT analysis. Representative micro-CT images of each type of TI implanted in the calvarial defect. Yellow dotted lines indicate the original defect margins. The calcified area was determined from the micro-CT images (n = 8, *p < 0.05). (C) Bone reparation evaluated by histological analysis with Goldner's trichrome staining. Red arrows indicate the original defect margins. Scale bar indicates 1 mm. The area of bone reparation was determined by histomorphometric analysis (n = 8, *p < 0.05). Color images available online at www.liebertpub.com/tea