Increased connectivity at the resection region is associated with seizure freedom after surgery. Postoperative seizure freedom is more common in patients with predominantly increased connectivity at the resection region (mean voxel t-score > 0.2, n = 24) compared to those with neutral (−0.2 < t < 0.2, n = 15) or decreased (t < 0.2, n = 23) connectivity (χ2 = 8.5, P = 0.015, all 61 patients). Results reflect regional connectivity between the resection region and the rest of the brain, compared to corresponding voxels in the non-epileptogenic hemisphere.