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. 2016 Apr 22;17:16. doi: 10.1186/s12868-016-0250-2

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© Lariosa-Willingham et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Half maximal effective concentration determination of four different GSIs for the promotion of myelination in the cortical culture assay. Dose response data confirm the activity of GSIs and enable the calculation of the EC₅₀ value for each compound. Cortical cultures were treated for 8 days with DAPT, LY 411,575, BMS 708,163 or MRK 560 and immunostained for MBP, Olig2 and DAPI. Dose–response curve for DAPT is compiled from n = 3 experiments, 80 image fields per concentration. Representative dose–response curves for LY 411,575, BMS 708,163 and MRK 560 are 32 image fields per concentration, mean ± SEM. Respective EC₅₀ values are shown in the legend